last updated: 9 December 2003

Purugganan, Michael D.

Michael Purugganan is currently an associate professor of genetics at North Carolina State University, working in the field of plant evolutionary genomics. He obtained his B.S. at the University of the Philippines at Diliman, his M.A. at Columbia University in New York and his Ph.D. at the University of Georgia. He spent two years as an Alfred P. Sloan Postdoctoral Fellow at the University of California at San Diego before starting his faculty position at NC State in 1996. He is the recipient of an Alfred P. Sloan Young Investigator Award, a Sigma Xi Research Award and an NC State Faculty Research Award.

Personal homepage: http://www.cals.ncsu.edu/genetics/purugganan/purugganan.html

Field of study: genetics, evolution, botany

Research title: Evolutionary genetics of plants

Research summary: Research focuses on the molecular genetic mechanisms underlying evolutionary adaptation and the evolution of plant genome diversity.

Publications:

A. Molecular Evolution of Development

Molecular evolution of duplicate redundant floral regulatory genes
Moore, R.C. and Purugganan, M.D.
Mol. Biol. Evol. (in preparation)

Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles
Olsen, K.M., Haldorsdottir, S., Stinchcombe, J., Weinig, C., Schmitt, J. and Purugganan, M.D.
Genetics (submitted)

Molecular evolution of molecular genetic pathways
Cork, J.M. and Purugganan, M.D.
Bioessays (in revision)

Molecular population genetics of the Arabidopsis CLAVATA2 genomic region: The genomic scale of balanced polymorphisms in a selfing species
Shepard, K.A. and Purugganan, M.D.
Genetics 163: 1083-1095 (2003)

Contrasting evolutionary forces in the Arabidopsis floral developmental pathway
Olsen, K.M., Womack, A., Garret, A.R., Suddith, J.I. and Purugganan, M.D.
Genetics 160: 1641 - 1650 (2002)

The genetics of plant morphological evolution
Shepard, K.A. and Purugganan, M.D.
Curr. Op. Plant Biol. 5: 49 - 55 (2002)

Molecular population genetics of regulatory genes
Purugganan, M.D.
Mol. Ecol. 9: 1451 - 1461 (2000)

Molecular evolution of flower development
Lawton-Rauh, A.L., Alvarez-Buylla, E.A. and Purugganan, M.D.
Trends Ecol. Evol. 15: 144 – 149 (2000)

Molecular population genetics of the Arabidopsis APETALA3 and PISTILLATA loci, floral homeotic genes that regulate petal and stamen development
Purugganan, M.D. and J. I. Suddith
Genetics 151: 839 - 848 (1999)

Patterns of molecular evolution among paralogous floral homeotic genes
Lawton-Rauh, A., Buckler, E., and Purugganan, M.D.
Molecular Biology and Evolution 16: 1037-1045 (1999)

Molecular population genetics of the Arabidopsis CAULIFLOWER regulatory gene: Nonneutral evolution and naturally occurring variation on floral homeotic function
Purugganan, M.D. and Suddith, J.I.
Proc. Natl. Acad. Sci. USA 95: 8130 - 8134 (1998)

The molecular evolution of development
Purugganan, M.D.
BioEssays 20: 700 - 711 (1998)

The MADS-box floral homeotic gene lineages predate the origin of the seed plants: Phylogenetic and molecular clock estimates
Purugganan, M.D.
J. Mol. Evol. 45: 392-396 (1997)

Molecular evolution of flower development: Diversification of the plant MADS-box regulatory gene family
Purugganan, M.D., Rounsley, S.D., Schmidt, R.J. and Yanofsky, M.F.
Genetics 140: 345 - 356 (1995)

Molecular evolution of the plant R regulatory gene family
Purugganan, M.D. and Wessler, S. R.
Genetics 138: 849 - 854 (1994)

B. Evolution of the Plant Genome

The early stages of duplicate gene evolution
Moore, R.C. and Purugganan, M.D.
Proc. Natl. Acad. Sci. USA (in press)

Plant population genomics, linkage disequilibrium and the genetics of adaptation
Olsen, K.M. and M.D. Purugganan
Can. J. Botany (in press)

Epialleles via methylation – plant population epigenetic consequences
Kalisz, S. M. and M.D. Purugganan
Trends Ecol. Evol. (in revision)

Selection on rapidly-evolving proteins in the Arabidopsis genome
Barrier, M. Bustamante, C. Yu, J. and Purugganan, M.D.
Genetics 163: 723-733 (2003)

Linking molecular insights and ecological research
Jackson, R., Linder, C.R., Lynch,M., Purugganan, M.D., Sommerville, S. and S. Thayer
Trends Ecol. Evol. 17: 409-414 (2002)

The cost of inbreeding in Arabidopsis
Bustamante, C., Nielsen, R., Sawyer, S., Olsen, K.M., Purugganan, M.D. and Hartl, D.L.
Nature 416: 531 - 534 (2002)

The evolution of the conserved ATPAse domain (CAD): Reconstructing the history of an ancient protein module
Swaffield, J.C. and Purugganan, M.D.
J. Mol. Evol. 45: 549-563 (1997)

C. Quantitative developmental genetics and ecology

Genotype-environment interactions at quantitative trait loci affecting inflorescence development in Arabidopsis thaliana
Ungerer, M.C., Halldorsdottir, S., Purugganan, M.D. and Mackay, T.F.C.
Genetics.165: 353 – 365 (2003)

Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana
Weinig, C., Dorn, L.A., Kane, N.C., Ungerer, M.C., Halldorsdottir, S., German, Z., Toyonaga, Y., Mackay, T.F.C., Purugganan, M.D. and Johanna Schmitt
Genetics 165: 321 - 329 (2003)

The genetics of functional trait evolution
Remington, D.L. and Purugganan, M.D.
Int. J. Plant Sci. 164: S7-S20 (2003)

Novel loci control variation in repruductive timing in Arabidopsis thaliana in natural environments
Weinig, C., Ungerer, M., Dorn, L.A., Kane. N.C., Halldorsdottir, S., Mackay, T.F.C., Purugganan, M.D. and Schmitt, J.I
Genetics 162: 1875-1881 (2002)

Quantitative trait loci for inflorescence development in Arabidopsis thaliana
Ungerer, M.C., Halldorsdottir, S., Modliszewski, J., Mackay, T.F.C. and Purugganan, M.D.
Genetics 160: 1133 - 1151 (2002)

Map-based cloning of quantitative trait loci: Progress and prospects
Remington, D.L., Ungerer, M.C. and Purugganan, M.D.
Genet. Res. 78: 213 - 218 (2001)

The genetic architecture of quantitative variation in the floral morphology of Arabidopsis
Juenger, T.E., Purugganan, M.D. and Mackay, T.F.C.
Genetics 156: 1379 - 1392 (2000)

D. Evolution of Adaptive Radiations

Adaptive radiation and regulatory gene evolution in the Hawaiian silversword alliance (Asteraceae)
Robichaux, R.H. and M.D. Purugganan
Annals Missouri Bot. Garden (in press)

Molecular population genetics of duplicate floral regulatory genes in polyploid Hawaiian silversword alliance species
Lawton-Rauh, A.L., Robichaux, R.H. and Purugganan, M.D.
Mol Ecol. 12: 1301 – 1313 (2003)

Molecular evolution of GAI homologues in the Hawaiian silversword alliance
Remington, D.L. and Purugganan, M.D.
Mol. Biol. Evol. 19: 1563 - 1574 (2002)

Accelerated regulatory gene evolution in a plant adaptive radiation
Barrier, M., Robichaux, R.H. and Purugganan, M.D.
Proc. Natl. Acad. Sci. USA. 98: 10208 - 10213 (2001)

Interspecific evolution in plant microsatellite structure
Barrier, M., Friar, E.A., Robichaux, R.H. and Purugganan, M.D.
Gene 241: 101 - 105 (2000)

Interspecific hybrid ancestry of a plant adaptive radiation: Allopolyploidy of the Hawaiian silversword alliance inferred from duplicated floral homeotic genes
Barrier, M., Baldwin, B., Robichaux, R.H., and Purugganan, M.D.
Molecular Biology and Evolution 16: 1105 - 1113 (1999)

E. Evolution of Domesticated Species

Molecular evidence on the origin and evolution of glutinous rice
Olsen, K.M., and Purugganan, M.D.
Genetics 162: 941-950 (2002)

Variation and selection at the CAULIFLOWER floral homeotic gene accompanying the evolution of domesticated Brassica oleracea
Purugganan, M.D., Boyles, A.L. and Suddith, J.I.
Genetics 155: 855 - 862 (2000)

Duplication of the Brassica oleracea APETALA1 floral homeotic gene and the evolution of domesticated cauliflower
Lowman, A.C. and Purugganan, M.D.
J. Heredity 90: 514 - 520 (1999)

F. Transposable Element Evolution

Purugganan. M.D. (1998). The splicing of transposable elements: A nuclear defense against genomic invasions?
In Horizontal Gene Transfer: Implications and Consequences (Ed. M. Syvanen), Chapman-Hall.

Transposon signatures: Species-specific molecular markers that utilize a class of multiple-copy nuclear DNA
Purugganan, M.D. and Wessler, S.R.
Molecular Ecology 4: 265 - 269 (1995)

Molecular evolution of Magellan, a maize Ty3/gypsy-like retrotransposon
Purugganan, M.D. and Wessler, S.R.
Proc. Natl. Acad. Sci. USA. 91: 11674 - 11678 (1994)

Transposable elements as introns: Evolutionary connections
Purugganan, M.D.
Trends in Ecol. Evol. 8: 239-243 (1993)

The splicing of transposable elements and its role in intron evolution
Purugganan, M.D. and Wessler, S.R.
Genetica 86: 295-303 (1992)
Reprinted in Transposable Elements and Evolution (J.F. McDonald, ed.) Dordrecht: Kluwer Publishing, 1993.

Alternative splicing induced by insertion of retrotransposons into the maize waxy gene
Purugganan, M.D., Varagona, M.J. and Wessler, S.R.
Plant Cell 4: 811-820 (1992)

Filler DNA is associated with spontaneous deletion breakpoints in maize
Wessler, S.R., Tarpley, A., Purugganan, M.D., Spell, M. and Okagaki, R.J.
Proc. Natl. Acad. Sci. USA 87: 8731-8735 (1990)

G. Others (Evolution and Ecology)

Intron and polypeptide evolution of conserved NPA-to-NPA motif regions in plant aquaporins
Xie, J.H., Wehner, T.C., Wollenberg, K., Purugganan, M.D. and Conkling, M.A.
J. Amer. Hort. Soc. 128: 591-597 (2003)

Scale-invariant spatial patterns in genome organization
Purugganan, M.D.
Phys. Lett. A. 175: 252-256 (1993)

H. Biophysical Chemistry

The fractal nature of RNA secondary structure
Purugganan, M.D.
Naturwiss. 76: 471-473 (1989)

Accelerated electron transfer between metal complexes mediated by DNA
Purugganan, M.D., Kumar, C.V., Turro, N.J. and Barton, J.K.
Science 241: 1645-1649 (1988)

A heuristic algorithm to determine the secondary structure of RNA
Purugganan, M.D. and Casimiro, D.R.
Nat. Appl. Sci. Bull. 37: 125-139. (1985)

A lattice statistical formulation for ligand binding to biological macromolecules
Purugganan, M.D.
Nat. Appl. Sci. Bull. 36: 215-218 (1984)

Parameters of hemoglobin cooperativity models from Hill plot binding data
Casimiro, D.R. and Purugganan, M.D.
Nat. Appl. Sci. Bull. 36: 207-214 (1984)

I. General papers (Non-reviewed)

Genes in ecology
Purugganan, M.D. and G. Gibson
Mol. Ecol. 12: 1109-112 (2003)

Book review: The evolutionary biology of plants
Purugganan, M.D.
Amer. Sci. 86: 79-81 (1998)

Evolution of development: Molecules, mechanisms and phylogenetics
Purugganan, M.D.
Trends in Ecol. Evol. 11: 5 - 7 (1996)